Higher Sensitivity Dopamine Measurements with Faster-Scan Cyclic Voltammetry
نویسندگان
چکیده
منابع مشابه
Simultaneous measurement and quantitation of 4-hydroxyphenylacetic acid and dopamine with fast-scan cyclic voltammetry.
Caged compounds have been used extensively to investigate neuronal function in a variety of preparations, including cell culture, ex vivo tissue samples, and in vivo. As a first step toward electrochemically measuring the extent of caged compound photoactivation while also measuring the release of the catecholamine neurotransmitter, dopamine, fast-scan cyclic voltammetry at carbon-fiber microel...
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Extensive research has focused on the neurotransmitter dopamine because of its importance in the mechanism of action of drugs of abuse (e.g. cocaine and amphetamine), the role it plays in psychiatric illnesses (e.g. schizophrenia and Attention Deficit Hyperactivity Disorder), and its involvement in degenerative disorders like Parkinson's and Huntington's disease. Under normal physiological cond...
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BACKGROUND Dopamine is a potent neuromodulator in the brain, influencing a variety of motivated behaviors and involved in several neurologic diseases. Measurements of extracellular dopamine in the brains of experimental animals have traditionally focused on a tonic timescale (minutes to hours). However, dopamine concentrations are now known to fluctuate on a phasic timescale (subseconds to seco...
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1. Introduction Rapid, transient changes in extracellular dopamine concentrations following salient stimuli in freely moving rats have recently been detected using fast-scan cyclic voltammetry (1,2). This type of neurotransmission had not been previously observed (for any neurotransmitter), but has been implicated by electrophysiological studies. Schultz et al. (3) reported synchronous burst fi...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2011
ISSN: 0003-2700,1520-6882
DOI: 10.1021/ac200143v